NATIONAL OPEN UNIVERSITY OF NIGERIA

UNIVERSITY VILLAGE, PLOT 91, CASDASTRAL ZONE, NNAMDI AZIKIWE EXPRESS WAY, JABI, ABUJA.
FACULTY OF SCIENCES
OCTOBER 2013 EXAMINATION

COURSE CODE:                                                                              BIO301

COURSE TITLE:                                                                             Genetics II

DURATION:                                                                                     2 Hours

INSTRUCTIONS:                                                                            Answer any 4 questions

Q1.a    (i)        Define population cytogenetics.

            (ii)       Discuss the genetic significance of de

       b.  (i)        Mention the goals of population genetics.

            (ii)       Describe the different types of duplications, and list their effect

Q2.a     (i)        Enumerate the role of structural chromosomal aberrations in plant breeding

            (ii)       Describe the mode of occurrence of the different types of inversions you know.

      b.   Polyploids are of significant effects, Discuss

Q3.a     (i)        How do genes determine sex?

            (ii)       Describe the structure of protein

      b.   (i)        What are the components of a ribosome?

            (ii)       Describe the various stages involved in transcription

Q4.a     (i)        What do you understand by the term pedigree?

            (ii)       Write short notes on the following:

(a)       Karyotype      (b)       Codominance             (c)       Dosage compensation.

      b.   Explain why sickle cell anemia is regarded as a heritable disease. 

Q5.a     (i)        What do you understand by the term paralogous?

            (ii)       Briefly discuss the origin of polyploidy.

      b.   (i)        List the characteristics of X-linked traits

            (ii)       Write short notes on the following:

(a)       silent mutation          (c)       missence mutation    (c)       point mutation

Q6.a     (i)        What do you understand by the term mutagens?

            (ii)       Describe the mode of action of the following mutagens:

(a)       Nitrous acid               (b)       A base Analog            (c)       UV light

     b.    (i)        Define genetic transfer.

            (ii)       How can you tell if there are any mutant colonies in a culture?