NATIONAL OPEN UNIVERSITY OF NIGERIA

UNIVERSITY VILLAGE, PLOT 91, CASDASTRAL ZONE, NNAMDI AZIKIWE EXPRESS WAY, JABI, ABUJA.
FACULTY OF SCIENCES
OCTOBER/NOVEMBER 2014 EXAMINATION

COURSE CODE:                                                                              BIO303

COURSE TITLE:                                                                             General Cytology

DURATION:                                                                                     2 Hours

INSTRUCTIONS:                                                                            Answer question 1 and any 4 questions

Q1.a     What is microscopy?                                                                                                                        (2 marks)

      b.   What are the 2 basic differences between optical and electron microscopes.                (2marks)

      c.    Itemise and state the functions of the essential components of a microscope.                         (10 marks)

     d.    What significant feature of the microscope determines the magnification of the

viewed specimen?                                                                                                                   (2marks)

     e.    Differentiate between cell growth and differentiation                                                       (2marks)

     f.     What are 3 unique components of fluorescence microscopy?                                         (3marks)

     g.    State and describe the 4 structural chromosomal variations                                            (4marks)

  (Total 25marks)

 Q2.a    Describe the general procedures employed in cytogenetic techniques                                      (8 marks)

       b.  Give an account of karyotyping                                                                                           (7 marks)

 (Total 15 marks)

Q3.      Compare and  contrast  the  nature,  principles  and  functions,  stating  the

advantages and disadvantages of the phase contrast and dark field

microscopes.                                                                                                                                    (15 marks)

 Q4.      Write precisely on the principles (5marks) and methods (10 marks) in

autoradiography.                                                                                                       (Total 15 marks)

 Q5.a    Describe the nature (3 marks), principles (1 marks) and uses           (3 marks)

of the electron microscopes.

       b.  What are the advantages and disadvantages of the tool (8marks).                (Total 15 marks)

 Q6.      Enumerate and describe the different phases of cell cycle.                                             (15 marks)