NATIONAL OPEN UNIVERSITY OF NIGERIA

UNIVERSITY VILLAGE, PLOT 91, CASDASTRAL ZONE, NNAMDI AZIKIWE EXPRESS WAY, JABI, ABUJA.
FACULTY OF SCIENCES
MARCH/APRIL 2016 EXAMINATION

COURSE CODE:           BIO 305

COURSE TITLE:            MOLECULAR BIOLOGY

CREDIT UNIT:              2

TIME ALLOWED:         2 Hours

INSTRUCTION: Answer question ONE (1) and any other THREE (3) questions

1ai.      What is molecular biology?                                                                                                    (3 marks)

   ii.      Describe the structures of the DNA.                                                                                       (8 marks)

  bi.      Outline the important features of glycolysis.                                                                         (6 marks)

   ii.      Give a detailed description of hormonal control of gene-expression.                                  (8 marks)

2a.       Describe the process of oxidative phosphorylation.                                                              (7 marks)

  b.       Give an account of any two methods of determining DNA sequences.                                 (8 marks)

3a.       What is DNA sequencing?                                                                                                       (2 marks)

  b.       Write short notes on each of the following:

            (i)         Chromosome number                                                                                                 (4 marks)

            (ii)        Sex chromosomes                                                                                                       (4 marks)

            (iii)       Acistron                                                                                                                       (4 marks)

5a        Summarize the roles of DNA and RNA                                                                                   (5 marks)

 b         Write short notes on each of the following:

            i.          Promoter clearance                                                                                                    (3 marks)

            ii.         Chain elongation                                                                                                         (3 marks)

            iii.        Termination of transcription                                                                                      (3 marks)

6a.       Outline the major components of a nucleotide                                                                     (5 marks)

  b.       With the help of a good illustration, describe the central dogma                                       (10 marks)