NATIONAL OPEN UNIVERSITY OF NIGERIA

UNIVERSITY VILLAGE, PLOT 91, CASDASTRAL ZONE, NNAMDI AZIKIWE EXPRESS WAY, JABI, ABUJA.
FACULTY OF SCIENCES
APRIL 2019 EXAMINATION

COURSE CODE: BIO 415

COURSE TITLE: VIROLOGY AND TISSUE CULTURE

TIME ALLOWED: 2 HOURS

INSTRUCTION: ANSWER QUESTION ONE (1) AND ANY OTHER THREE (3) QUESTIONS

1. (a) Define the term virology (3 marks)   

    (b) Describe the chemical composition of viruses (12 marks)

     (c)  The future prospects in vaccination is bright through the combination of molecular biology and modern technologies. Discuss (10 marks).

2. (a) Enumerate any 6 characteristics of viruses (6 marks)     

    (b) Describe the various modes of infection transmission by viruses (9 marks)

3. (a) What do you understand by the term viral replication? (3 marks)

    (b) Write short notes on the following stages of viral replication:  

        i. Morphogenesis (3 marks)

        ii. Transcription (3 marks)

       iii. Maturity and release (3 marks)

4. (a) In a tabular form, list 10 medically important viruses indicating their characteristic symmetry and shapes (10 marks)

(b) In a tabular form, list 10 medically important viruses and infection caused by each of them   (5marks)

5. (a) Outline the conditions that are necessary for a good diagnosis of virus infections.(8 marks)

  (b) Distinguish between DNA and RNA viral genomes (4 marks)

  (c) An RNA virus contains the following sequence: T A G G G C T T A. What will be the

       sequence on the complementary strand in its cDNA? (3 marks)